COUP-TFII

Factor de transcripción COUP2
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	COUP-TFII (HGNC: 7976) ARP1; COUP-TFII; COUPTFB; MGC117452; SVP40; TFCOUP2
Identificadores; externos	OMIM: 107773 ; EBI: COUP-TFII; GeneCards: Gen COUP-TFII; UniProt: COUP-TFII;
Locus	Cr. 15 q26.2
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
7026
P24468	n/a
NP_066285	n/a
	v; t; e;
	[editar datos en Wikidata]

El factor de transcripción COUP2 (COUP-TFII), también conocido como NR2F2 (de sus siglas en inglés "Nuclear receptor subfamily 2, group F, member 2"), es una proteína codificada en humanos por el gen HGNC NR2F2 .^[1]

COUP-TFII juega un papel crucial en el control del desarrollo de un cierto número de tejidos y órganos incluido el corazón, los vasos sanguíneos, el músculo y los miembros.^[2]^[3] El receptor de glucocorticoides (GR) estimula la transactivación inducida por COUP-TFII, mientras que COUP-TFII reprime la actividad transcripcional de GR.^[4]^[5] COUP-TFII interacciona con GATA2 para inhibir la diferenciación de los adipocitos.^[6]

Interacciones

La proteína COUP-TFII ha demostrado ser capaz de interaccionar con:

Referencias

↑ «Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2».
↑ Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (abril de 1999). «The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development». Genes Dev. 13 (8): 1037-49. PMC 316637. PMID 10215630. doi:10.1128/MCB.24.24.10835-10843.2004.
↑ Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (diciembre de 2004). «The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development». Mol. Cell. Biol. 24 (24): 10835-43. PMC 533959. PMID 15572686. doi:10.1128/MCB.24.24.10835-10843.2004.
↑ De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (abril de 2004). «The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism». Mol. Endocrinol. 18 (4): 820-33. PMID 14739255. doi:10.1210/me.2003-0341.
↑ De Martino MU, Alesci S, Chrousos GP, Kino T (junio de 2004). «Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism». Ann. N. Y. Acad. Sci. 1024: 72-85. PMID 15265774. doi:10.1196/annals.1321.006.
↑ Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (febrero de 2008). «The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis». Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421-6. PMID 18250317. doi:10.1073/pnas.0707082105.
↑ Smirnov, D A; Hou S, Ricciardi R P (Mar. de 2000). «Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription». Virology (UNITED STATES) 268 (2): 319-28. ISSN 0042-6822. PMID 10704340. doi:10.1006/viro.1999.0181.
↑ Avram, D; Ishmael J E, Nevrivy D J, Peterson V J, Lee S H, Dowell P, Leid M (mayo. de 1999). «Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2». J. Biol. Chem. (UNITED STATES) 274 (20): 14331-6. ISSN 0021-9258. PMID 10318855.
↑ Marcus, S L; Winrow C J, Capone J P, Rachubinski R A (Nov. de 1996). «A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor». J. Biol. Chem. (UNITED STATES) 271 (44): 27197-200. ISSN 0021-9258. PMID 8910285.

Datos: Q18031959

[entrez-1] «Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2».

[pmid10215630-2] Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY (abril de 1999). «The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development». Genes Dev. 13 (8): 1037-49. PMC 316637. PMID 10215630. doi:10.1128/MCB.24.24.10835-10843.2004.

[pmid15572686-3] Lee CT, Li L, Takamoto N, Martin JF, Demayo FJ, Tsai MJ, Tsai SY (diciembre de 2004). «The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development». Mol. Cell. Biol. 24 (24): 10835-43. PMC 533959. PMID 15572686. doi:10.1128/MCB.24.24.10835-10843.2004.

[pmid14739255-4] De Martino MU, Bhattachryya N, Alesci S, Ichijo T, Chrousos GP, Kino T (abril de 2004). «The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism». Mol. Endocrinol. 18 (4): 820-33. PMID 14739255. doi:10.1210/me.2003-0341.

[pmid15265774-5] De Martino MU, Alesci S, Chrousos GP, Kino T (junio de 2004). «Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism». Ann. N. Y. Acad. Sci. 1024: 72-85. PMID 15265774. doi:10.1196/annals.1321.006.

[pmid18250317-6] Xu Z, Yu S, Hsu CH, Eguchi J, Rosen ED (febrero de 2008). «The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis». Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421-6. PMID 18250317. doi:10.1073/pnas.0707082105.

[pmid10704340-7] Smirnov, D A; Hou S, Ricciardi R P (Mar. de 2000). «Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription». Virology (UNITED STATES) 268 (2): 319-28. ISSN 0042-6822. PMID 10704340. doi:10.1006/viro.1999.0181.

[pmid10318855-8] Avram, D; Ishmael J E, Nevrivy D J, Peterson V J, Lee S H, Dowell P, Leid M (mayo. de 1999). «Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2». J. Biol. Chem. (UNITED STATES) 274 (20): 14331-6. ISSN 0021-9258. PMID 10318855.

[pmid8910285-9] Marcus, S L; Winrow C J, Capone J P, Rachubinski R A (Nov. de 1996). «A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor». J. Biol. Chem. (UNITED STATES) 271 (44): 27197-200. ISSN 0021-9258. PMID 8910285.

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