RAD9A

Proteína de punto de control del ciclo celular RAD9A
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Estructuras enzimáticas RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos	RAD9A (HGNC: 9827) RAD9
Identificadores; externos	OMIM: 603761 ; EBI: RAD9A; GeneCards: Gen RAD9A; UniProt: RAD9A; Bases de datos de enzimas IntEnz: entrada en IntEnz; BRENDA: entrada en BRENDA; ExPASy: NiceZime view; KEGG: entrada en KEEG; PRIAM: perfil PRIAM; ExplorEnz: entrada en ExplorEnz; MetaCyc: vía metabólica
Número EC	3.11.1.2
Locus	Cr. 11 q13.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
5883
Q99638	n/a
NP_004575	n/a
[1] ;
[2]
	v; t; e;
	[editar datos en Wikidata]

La proteína de punto de control del ciclo celular RAD9A es una proteína codificada en humanos por el gen RAD9A.^[1]

Este producto génico es muy similar a la proteína RAD9 de Schizosaccharomyces pombe, una proteína de punto de control del ciclo celular requerida para que se produzca la parada del ciclo celular y la reparación del ADN en caso de que este haya sufrido daño. RAD9A posee actividad exonucleasa 3' y 5', con lo que podría contribuir en la detección y reparación del ADN dañado. Forma un complejo proteico de punto de control junto con RAD1 y HUS1. Este complejo es reclutado por la proteína de punto de control RAD17 hacia aquellos puntos donde el ADN ha sufrido daño, por lo que parece ser importante en la puesta en marcha de la cascada de señalización implicada en la parada de punto de control. Se ha descrito un uso alternativo de sitios de poli-A en este gen.^[2]

Interacciones

La proteína RAD9A ha demostrado ser capaz de interaccionar con:

Referencias

↑ Lieberman HB, Hopkins KM, Nass M, Demetrick D, Davey S (Jan de 1997). «A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene». Proc Natl Acad Sci U S A 93 (24): 13890-5. PMC 19459. PMID 8943031.
↑ «Entrez Gene: RAD9A RAD9 homolog A (S. pombe)».
↑ ^a ^b ^c Dufault, Vanessa M; Oestreich Andrea J, Vroman Benjamin T, Karnitz Larry M (Dec. de 2003). «Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene». Genomics (United States) 82 (6): 644-51. ISSN 0888-7543. PMID 14611806.
↑ Bermudez, Vladimir P; Lindsey-Boltz Laura A, Cesare Anthony J, Maniwa Yoshimasa, Griffith Jack D, Hurwitz Jerard, Sancar Aziz (Feb. de 2003). «Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 1633-8. ISSN 0027-8424. PMID 12578958. doi:10.1073/pnas.0437927100.
↑ Rauen, M; Burtelow M A, Dufault V M, Karnitz L M (Sep. de 2000). «The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9». J. Biol. Chem. (UNITED STATES) 275 (38): 29767-71. ISSN 0021-9258. PMID 10884395. doi:10.1074/jbc.M005782200.
↑ ^a ^b Lindsey-Boltz, L A; Bermudez V P, Hurwitz J, Sancar A (Sep. de 2001). «Purification and characterization of human DNA damage checkpoint Rad complexes». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (20): 11236-41. ISSN 0027-8424. PMID 11572977. doi:10.1073/pnas.201373498.
↑ Cai, R L; Yan-Neale Y, Cueto M A, Xu H, Cohen D (Sep. de 2000). «HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins». J. Biol. Chem. (UNITED STATES) 275 (36): 27909-16. ISSN 0021-9258. PMID 10846170. doi:10.1074/jbc.M000168200.
↑ Mäkiniemi, M; Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä T P, Syväoja J E (Aug. de 2001). «BRCT domain-containing protein TopBP1 functions in DNA replication and damage response». J. Biol. Chem. (United States) 276 (32): 30399-406. ISSN 0021-9258. PMID 11395493. doi:10.1074/jbc.M102245200.
↑ ^a ^b Volkmer, E; Karnitz L M (Jan. de 1999). «Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex». J. Biol. Chem. (UNITED STATES) 274 (2): 567-70. ISSN 0021-9258. PMID 9872989.
↑ ^a ^b Griffith, Jack D; Lindsey-Boltz Laura A, Sancar Aziz (mayo. de 2002). «Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy». J. Biol. Chem. (United States) 277 (18): 15233-6. ISSN 0021-9258. PMID 11907025. doi:10.1074/jbc.C200129200.
↑ ^a ^b Hirai, Itaru; Wang Hong-Gang (Jul. de 2002). «A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex». J. Biol. Chem. (United States) 277 (28): 25722-7. ISSN 0021-9258. PMID 11994305. doi:10.1074/jbc.M203079200.
↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.
↑ ^a ^b Komatsu, K; Miyashita T, Hang H, Hopkins K M, Zheng W, Cuddeback S, Yamada M, Lieberman H B, Wang H G (Jan. de 2000). «Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis». Nat. Cell Biol. (ENGLAND) 2 (1): 1-6. ISSN 1465-7392. PMID 10620812. doi:10.1038/71316.
↑ Wang, Liang; Hsu Cheng-Lung, Ni Jing, Wang Peng-Hui, Yeh Shuyuan, Keng Peter, Chang Chawnshang (Mar. de 2004). «Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells». Mol. Cell. Biol. (United States) 24 (5): 2202-13. ISSN 0270-7306. PMID 14966297.
↑ Xiang, S L; Kumano T, Iwasaki S I, Sun X, Yoshioka K, Yamamoto K C (Oct. de 2001). «The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9». Biochem. Biophys. Res. Commun. (United States) 287 (4): 932-40. ISSN 0006-291X. PMID 11573955. doi:10.1006/bbrc.2001.5685.
↑ Yoshida, Kiyotsugu; Komatsu Kiyoshi, Wang Hong-Gang, Kufe Donald (mayo. de 2002). «c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage». Mol. Cell. Biol. (United States) 22 (10): 3292-300. ISSN 0270-7306. PMID 11971963.

Datos: Q18031007

[pmid8943031-1] Lieberman HB, Hopkins KM, Nass M, Demetrick D, Davey S (Jan de 1997). «A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene». Proc Natl Acad Sci U S A 93 (24): 13890-5. PMC 19459. PMID 8943031.

[entrez-2] «Entrez Gene: RAD9A RAD9 homolog A (S. pombe)».

[pmid14611806-3] Dufault, Vanessa M; Oestreich Andrea J, Vroman Benjamin T, Karnitz Larry M (Dec. de 2003). «Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene». Genomics (United States) 82 (6): 644-51. ISSN 0888-7543. PMID 14611806.

[pmid12578958-4] Bermudez, Vladimir P; Lindsey-Boltz Laura A, Cesare Anthony J, Maniwa Yoshimasa, Griffith Jack D, Hurwitz Jerard, Sancar Aziz (Feb. de 2003). «Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro». Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (4): 1633-8. ISSN 0027-8424. PMID 12578958. doi:10.1073/pnas.0437927100.

[pmid10884395-5] Rauen, M; Burtelow M A, Dufault V M, Karnitz L M (Sep. de 2000). «The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9». J. Biol. Chem. (UNITED STATES) 275 (38): 29767-71. ISSN 0021-9258. PMID 10884395. doi:10.1074/jbc.M005782200.

[pmid11572977-6] Lindsey-Boltz, L A; Bermudez V P, Hurwitz J, Sancar A (Sep. de 2001). «Purification and characterization of human DNA damage checkpoint Rad complexes». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (20): 11236-41. ISSN 0027-8424. PMID 11572977. doi:10.1073/pnas.201373498.

[pmid10846170-7] Cai, R L; Yan-Neale Y, Cueto M A, Xu H, Cohen D (Sep. de 2000). «HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins». J. Biol. Chem. (UNITED STATES) 275 (36): 27909-16. ISSN 0021-9258. PMID 10846170. doi:10.1074/jbc.M000168200.

[pmid11395493-8] Mäkiniemi, M; Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Mäkelä T P, Syväoja J E (Aug. de 2001). «BRCT domain-containing protein TopBP1 functions in DNA replication and damage response». J. Biol. Chem. (United States) 276 (32): 30399-406. ISSN 0021-9258. PMID 11395493. doi:10.1074/jbc.M102245200.

[pmid9872989-9] Volkmer, E; Karnitz L M (Jan. de 1999). «Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex». J. Biol. Chem. (UNITED STATES) 274 (2): 567-70. ISSN 0021-9258. PMID 9872989.

[pmid11907025-10] Griffith, Jack D; Lindsey-Boltz Laura A, Sancar Aziz (mayo. de 2002). «Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy». J. Biol. Chem. (United States) 277 (18): 15233-6. ISSN 0021-9258. PMID 11907025. doi:10.1074/jbc.C200129200.

[pmid11994305-11] Hirai, Itaru; Wang Hong-Gang (Jul. de 2002). «A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex». J. Biol. Chem. (United States) 277 (28): 25722-7. ISSN 0021-9258. PMID 11994305. doi:10.1074/jbc.M203079200.

[pmid16189514-12] Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.

[pmid10620799-13] Komatsu, K; Miyashita T, Hang H, Hopkins K M, Zheng W, Cuddeback S, Yamada M, Lieberman H B, Wang H G (Jan. de 2000). «Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis». Nat. Cell Biol. (ENGLAND) 2 (1): 1-6. ISSN 1465-7392. PMID 10620812. doi:10.1038/71316.

[pmid14966297-14] Wang, Liang; Hsu Cheng-Lung, Ni Jing, Wang Peng-Hui, Yeh Shuyuan, Keng Peter, Chang Chawnshang (Mar. de 2004). «Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells». Mol. Cell. Biol. (United States) 24 (5): 2202-13. ISSN 0270-7306. PMID 14966297.

[pmid11573955-15] Xiang, S L; Kumano T, Iwasaki S I, Sun X, Yoshioka K, Yamamoto K C (Oct. de 2001). «The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9». Biochem. Biophys. Res. Commun. (United States) 287 (4): 932-40. ISSN 0006-291X. PMID 11573955. doi:10.1006/bbrc.2001.5685.

[pmid11971963-16] Yoshida, Kiyotsugu; Komatsu Kiyoshi, Wang Hong-Gang, Kufe Donald (mayo. de 2002). «c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage». Mol. Cell. Biol. (United States) 22 (10): 3292-300. ISSN 0270-7306. PMID 11971963.

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