MCM7

Proteína 7 de mantenimiento de mini-cromosomas (S. cerevisiae)
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos	MCM7 (HGNC: 6950) MCM2; CDABP0042; CDC47; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146
Identificadores; externos	OMIM: 600592 ; EBI: MCM7; GeneCards: Gen MCM7; UniProt: MCM7;
Locus	Cr. 7 q22.1
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
4176
P33993	n/a
NP_005907	n/a
	v; t; e;
	[editar datos en Wikidata]

La proteína 7 de mantenimiento de mini-cromosomas (MCM7) es una proteína codificada en humanos por el gen MCM7.^[1]

La proteína codificada por este gen es una de las implicadas en el mantenimiento de mini-cromosomas (MCM), que son esenciales para el inicio de la replicación del genoma eucariota. Las proteínas MCM forman un complejo hexamérico que es un componente clave del complejo pre-replicativo (pre-RC) y podría estar implicado en la formación de las horquillas de replicación y en el reclutamiento de otras proteínas asociadas a la replicación del ADN. La proteína MCM7, junto a MCM2, MCM4 y MCM6, poseen actividad ADN-helicasa, por lo que podrían actuar como enzimas de desenrollamiento del ADN. La proteína Cdk4 se encuentra asociada a MCM7 y podría regular su unión a la proteína supresora de tumores RB1/RB. Se han descrito diversas variantes transcripcionales de este gen, que codifican diferentes isoformas de la proteína.^[2]

Interacciones

La proteína MCM7 ha demostrado ser capaz de interaccionar con:

Véase también

Complejo de mantenimiento de mini-cromosomas

Referencias

↑ Nakatsuru S, Sudo K, Nakamura Y (Mar de 1995). «Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication». Cytogenet Cell Genet 68 (3-4): 226-30. PMID 7842741.
↑ «Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)».
↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. de 2003). «Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells». J. Mol. Biol. (England) 327 (1): 111-28. ISSN 0022-2836. PMID 12614612.
↑ Sterner, J M; Dew-Knight S, Musahl C, Kornbluth S, Horowitz J M (mayo. de 1998). «Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7». Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748-57. ISSN 0270-7306. PMID 9566894.
↑ ^a ^b ^c ^d ^e Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr. de 1997). «In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP». J. Biol. Chem. (UNITED STATES) 272 (16): 10928-35. ISSN 0021-9258. PMID 9099751.
↑ DaFonseca, C J; Shu F, Zhang J J (Mar. de 2001). «Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034-9. ISSN 0027-8424. PMID 11248027. doi:10.1073/pnas.061487598.
↑ ^a ^b ^c Yabuta, Norikazu; Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (mayo. de 2003). «Mammalian Mcm2/4/6/7 complex forms a toroidal structure». Genes Cells (England) 8 (5): 413-21. ISSN 1356-9597. PMID 12694531.
↑ ^a ^b ^c You, Zhiying; Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov. de 2002). «Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex». J. Biol. Chem. (United States) 277 (45): 42471-9. ISSN 0021-9258. PMID 12207017. doi:10.1074/jbc.M205769200.
↑ Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (Sep. de 1996). «Binding of human minichromosome maintenance proteins with histone H3». J. Biol. Chem. (UNITED STATES) 271 (39): 24115-22. ISSN 0021-9258. PMID 8798650.
↑ ^a ^b Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (Sep. de 1999). «Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation». J. Biol. Chem. (UNITED STATES) 274 (36): 25927-32. ISSN 0021-9258. PMID 10464337.
↑ Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (Mar. de 2002). «Nuclear organization of DNA replication initiation proteins in mammalian cells». J. Biol. Chem. (United States) 277 (12): 10354-61. ISSN 0021-9258. PMID 11779870. doi:10.1074/jbc.M111398200.
↑ Wang, Y; Xu F, Hall F L (Oct. de 2000). «The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor». FEBS Lett. (NETHERLANDS) 484 (1): 17-21. ISSN 0014-5793. PMID 11056214.
↑ You, Z; Komamura Y; Ishimi Y (Dec. de 1999). «Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity». Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003-15. ISSN 0270-7306. PMID 10567526.
↑ Kühne, C; Banks L (Dec. de 1998). «E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box». J. Biol. Chem. (UNITED STATES) 273 (51): 34302-9. ISSN 0021-9258. PMID 9852095.
↑ Kukimoto, I; Igaki H; Kanda T (Nov. de 1999). «Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha». Eur. J. Biochem. (GERMANY) 265 (3): 936-43. ISSN 0014-2956. PMID 10518787.

Datos: Q18028951

[pmid7842741-1] Nakatsuru S, Sudo K, Nakamura Y (Mar de 1995). «Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication». Cytogenet Cell Genet 68 (3-4): 226-30. PMID 7842741.

[entrez-2] «Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)».

[pmid12614612-3] ↑ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m Kneissl, Margot; Pütter Vera, Szalay Aladar A, Grummt Friedrich (Mar. de 2003). «Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells». J. Mol. Biol. (England) 327 (1): 111-28. ISSN 0022-2836. PMID 12614612.

[pmid9566894-4] Sterner, J M; Dew-Knight S, Musahl C, Kornbluth S, Horowitz J M (mayo. de 1998). «Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7». Mol. Cell. Biol. (UNITED STATES) 18 (5): 2748-57. ISSN 0270-7306. PMID 9566894.

[pmid9099751-5] Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr. de 1997). «In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP». J. Biol. Chem. (UNITED STATES) 272 (16): 10928-35. ISSN 0021-9258. PMID 9099751.

[pmid11248027-6] DaFonseca, C J; Shu F, Zhang J J (Mar. de 2001). «Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034-9. ISSN 0027-8424. PMID 11248027. doi:10.1073/pnas.061487598.

[pmid12694531-7] Yabuta, Norikazu; Kajimura Naoko, Mayanagi Kouta, Sato Michio, Gotow Takahito, Uchiyama Yasuo, Ishimi Yukio, Nojima Hiroshi (mayo. de 2003). «Mammalian Mcm2/4/6/7 complex forms a toroidal structure». Genes Cells (England) 8 (5): 413-21. ISSN 1356-9597. PMID 12694531.

[pmid12207017-8] You, Zhiying; Ishimi Yukio, Masai Hisao, Hanaoka Fumio (Nov. de 2002). «Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex». J. Biol. Chem. (United States) 277 (45): 42471-9. ISSN 0021-9258. PMID 12207017. doi:10.1074/jbc.M205769200.

[pmid8798650-9] Ishimi, Y; Ichinose S; Omori A; Sato K; Kimura H (Sep. de 1996). «Binding of human minichromosome maintenance proteins with histone H3». J. Biol. Chem. (UNITED STATES) 271 (39): 24115-22. ISSN 0021-9258. PMID 8798650.

[pmid10464337-10] Fujita, M; Yamada C; Goto H; Yokoyama N; Kuzushima K; Inagaki M; Tsurumi T (Sep. de 1999). «Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation». J. Biol. Chem. (UNITED STATES) 274 (36): 25927-32. ISSN 0021-9258. PMID 10464337.

[pmid11779870-11] Fujita, Masatoshi; Ishimi Yukio, Nakamura Hiromu, Kiyono Tohru, Tsurumi Tatsuya (Mar. de 2002). «Nuclear organization of DNA replication initiation proteins in mammalian cells». J. Biol. Chem. (United States) 277 (12): 10354-61. ISSN 0021-9258. PMID 11779870. doi:10.1074/jbc.M111398200.

[pmid11056214-12] Wang, Y; Xu F, Hall F L (Oct. de 2000). «The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor». FEBS Lett. (NETHERLANDS) 484 (1): 17-21. ISSN 0014-5793. PMID 11056214.

[pmid10567526-13] You, Z; Komamura Y; Ishimi Y (Dec. de 1999). «Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity». Mol. Cell. Biol. (UNITED STATES) 19 (12): 8003-15. ISSN 0270-7306. PMID 10567526.

[pmid9852095-14] Kühne, C; Banks L (Dec. de 1998). «E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box». J. Biol. Chem. (UNITED STATES) 273 (51): 34302-9. ISSN 0021-9258. PMID 9852095.

[pmid10518787-15] Kukimoto, I; Igaki H; Kanda T (Nov. de 1999). «Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha». Eur. J. Biochem. (GERMANY) 265 (3): 936-43. ISSN 0014-2956. PMID 10518787.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]