Receptor de hormona tiroidea alfa

Receptor de hormona tiroidea alfa
	; Estructura tridimensional del receptor TR-alfa.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1NAV , 2H77 , 2H79 , 3HZF , 3ILZ , 3JZB
Identificadores
Símbolos	THRA (HGNC: 11796) THRA1, THRA2, ERBA1
Identificadores; externos	OMIM: 190120 ; IUPHAR: NR1A1; HomoloGene: 37747 ; ChEMBL: 1860; EBI: THRA; GeneCards: Gen THRA; UniProt: THRA;
Locus	Cr. 17 q11.2-17q12
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
7067	21833
Véase HS	Véase MM
P10827	P63058
NM_001190918	NM_178060
NP_001177847	NP_835161
Cr. 17:; 38.21 – 38.25 Mb	Cr. 11:; 98.74 – 98.77 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

El receptor de hormona tiroidea alfa (TR-alfa) también conocido como NR1A1 (de sus siglas en inglés "nuclear receptor subfamily 1, group A, member 1"), es un receptor nuclear codificado, en humanos, por el gen HGNC THRA .^[1]

La proteína TR-alfa es un receptor nuclear de hormonas para triyodotironina. Es uno de los diversos receptores para hormonas tiroideas y ha demostrado estar implicado en la actividad biológica de la hormona tiroidea. Estudios llevados a cabo en ratones knockout sugieren que los diferentes receptores, mientras mantengan cierta redundancia, podrían mediar en las diferentes funciones de la hormona tiroidea. Se han descrito diferentes variantes por splicing alternativo que generan distintas isoformas del receptor.^[1]

Interacciones

El receptor de hormona tiroidea alfa ha demostrado ser capaz de interaccionar con:

Véase también

Receptor de hormona tiroidea

Referencias

↑ ^a ^b «Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)».
↑ Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404.
↑ Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915-25. ISSN 0888-8809. PMID 10847592.
↑ ^a ^b ^c Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. de 1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell (UNITED STATES) 3 (3): 361-70. ISSN 1097-2765. PMID 10198638.
↑ ^a ^b De Luca, Antonio; Severino Anna, De Paolis Paola, Cottone Giuliano, De Luca Luca, De Falco Maria, Porcellini Antonio, Volpe Massimo, Condorelli Gianluigi (Feb. de 2003). «p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor». Biochem. J. (England) 369 (Pt 3): 477-84. ISSN 0264-6021. PMID 12371907. doi:10.1042/BJ20020057.
↑ Chang, K H; Chen Y, Chen T T, Chou W H, Chen P L, Ma Y Y, Yang-Feng T L, Leng X, Tsai M J, O'Malley B W, Lee W H (Aug. de 1997). «A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9040-5. ISSN 0027-8424. PMID 9256431.
↑ Yuan, C X; Ito M, Fondell J D, Fu Z Y, Roeder R G (Jul. de 1998). «The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (14): 7939-44. ISSN 0027-8424. PMID 9653119.
↑ Li, D; Wang F, Samuels H H (Dec. de 2001). «Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation». Mol. Cell. Biol. (United States) 21 (24): 8371-84. ISSN 0270-7306. PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.
↑ Li, D; Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels H H (Oct. de 1999). «NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors». Mol. Cell. Biol. (UNITED STATES) 19 (10): 7191-202. ISSN 0270-7306. PMID 10490654.
↑ Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (mayo. de 1999). «Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily». Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383-94. ISSN 0270-7306. PMID 10207062.
↑ Tan, Fengwei; Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong (Jul. de 2008). «Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells». Proteomics (Germany) 8 (14): 2885-96. PMID 18655026. doi:10.1002/pmic.200700887.

Datos: Q18031986

[entrez-1] «Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)».

[pmid10567404-2] Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404.

[pmid10847592-3] Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915-25. ISSN 0888-8809. PMID 10847592.

[pmid10198638-4] Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. de 1999). «Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators». Mol. Cell (UNITED STATES) 3 (3): 361-70. ISSN 1097-2765. PMID 10198638.

[pmid12371907-5] De Luca, Antonio; Severino Anna, De Paolis Paola, Cottone Giuliano, De Luca Luca, De Falco Maria, Porcellini Antonio, Volpe Massimo, Condorelli Gianluigi (Feb. de 2003). «p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor». Biochem. J. (England) 369 (Pt 3): 477-84. ISSN 0264-6021. PMID 12371907. doi:10.1042/BJ20020057.

[pmid9256431-6] Chang, K H; Chen Y, Chen T T, Chou W H, Chen P L, Ma Y Y, Yang-Feng T L, Leng X, Tsai M J, O'Malley B W, Lee W H (Aug. de 1997). «A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9040-5. ISSN 0027-8424. PMID 9256431.

[pmid9653119-7] Yuan, C X; Ito M, Fondell J D, Fu Z Y, Roeder R G (Jul. de 1998). «The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (14): 7939-44. ISSN 0027-8424. PMID 9653119.

[pmid11713274-8] Li, D; Wang F, Samuels H H (Dec. de 2001). «Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation». Mol. Cell. Biol. (United States) 21 (24): 8371-84. ISSN 0270-7306. PMID 11713274. doi:10.1128/MCB.21.24.8371-8384.2001.

[pmid10490654-9] Li, D; Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels H H (Oct. de 1999). «NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors». Mol. Cell. Biol. (UNITED STATES) 19 (10): 7191-202. ISSN 0270-7306. PMID 10490654.

[pmid10207062-10] Dressel, U; Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A (mayo. de 1999). «Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily». Mol. Cell. Biol. (UNITED STATES) 19 (5): 3383-94. ISSN 0270-7306. PMID 10207062.

[pmid18655026-11] Tan, Fengwei; Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong (Jul. de 2008). «Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells». Proteomics (Germany) 8 (14): 2885-96. PMID 18655026. doi:10.1002/pmic.200700887.

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